Basic Information
VIS ID
TVIS44001942
Fusion event
HTLV-1-BICRA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
48131898/47628641 (Hg38)
End
48131898/47628641 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
BICRA
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-600 ; hsa-mir-3923 ; hsa-mir-3191-3p ; hsa-mir-4725-3p ; hsa-mir-6780b-5p ; hsa-mir-4271 ; hsa-mir-92b-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-3202 ; hsa-mir-6818-3p ; hsa-mir-582-5p
Nearest miRNA
hsa-mir-10395/Upstream/401620; hsa-let-7e/Downstream/1381265;
Nearest TSS
ENST00000633603/Upstream/2246; ENST00000614245/Downstream/50321;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/18213, chr19-CpG: 122/Downstream/51205
Nearest cancer related gene
BICRA(TSG, No orient, 0)
Upstream sequence
AAAGTCATATAACACGACGAAAGTCTTTGCACCATCTCCTCTTCTTTCCTTTTCCAAAGGTGACCTCTGTGGGGAGTTTGGGGCTcatggtctctctctg
Downstream sequence
ttgtccaggctggagtgcagtggcatgatcatagttcattgcagtctcaacatcctgggttcaggtgatccttccacctcagcctcctgagtagctgggg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate