Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene102578223102473303102533972102523568102525459102478278102480147102513218102515074102504291102506131102487128102488911102484574102485841102521177102522153102502352102503280102500000102500895102501362102502211102519706102520524102515569102516227102498724102499345102476790102477355102508998102509550102483016102483558102477548102478088102507160102507694102520621102521150102522815102523312102476301102476776102491990102492441102517934102518318102480449102480821102489665102490024102510286102510627102509820102510064102510911102511045102525763
Basic Information
VIS ID
TVIS44001944
Fusion event
HTLV-1-SLC9A4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
103142222/102525763 (Hg38)
End
103142222/102525763 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
SLC9A4
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-548l ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/93397; hsa-mir-10b/Downstream/6615727;
Nearest TSS
ENST00000437798/Upstream/22321; ENST00000467657/Downstream/93944;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/169627, chr2-CpG: 110/Downstream/93154
Upstream sequence
ATTTGAATGGAGGCTGGGTGAGAAGCAGACCTTAATCTCAAGCCTAACCTCAGTGGGGATACGAGAGTAACTTTGAAAGGTTGCTAATGGTCTATTTTAT
Downstream sequence
CATGAGAGGGGAAGGAAATACATGTTGGAGACTGGCGTGTTCTGCTTTCTCAAAACAAAAAAACTAAAAGCCAGTAATCCAAACAAGATGCCACAGAACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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