Basic Information
VIS ID
TVIS44001955
Fusion event
HTLV-1-JPT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73132538/75136443 (Hg38)
End
73132538/75136443 (Hg38)
Orient
+
Location type
Intronic
Target gene
JPT1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-3187-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-mir-10226/Upstream/387744; hsa-mir-1250/Downstream/269626;
Nearest TSS
ENST00000595228/Upstream/4648; ENST00000582833/Downstream/10337;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/4543, chr17-CpG: 115/Downstream/17095
Upstream sequence
TGATGGTTGGAAACATACCTAAAAGCATAAACAAAATAATCACCCACCATGCTCCCACTCCACAGAATTAACCATTGTTCATCTTTTCCCATATTTGTTG
Downstream sequence
TTTATGTTCTTTTCTAAATTACACAAATATATAAGGACATGAAgtttttttttgttttgttttgttttTTgacggagtctcgctgttgcccaggctggag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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