Basic Information
VIS ID
TVIS44001956
Fusion event
HTLV-1-RFX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
6091208/6091197 (Hg38)
End
6091208/6091197 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
RFX2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-151b ; hsa-mir-151a-5p ; hsa-mir-611 ; hsa-mir-3131 ; hsa-mir-4695-5p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p
Nearest miRNA
hsa-mir-1227/Upstream/1158457; hsa-let-7e/Downstream/298441;
Nearest TSS
ENST00000633603/Upstream/23244; ENST00000588342/Downstream/18125;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/50980, chr19-CpG: 22/Downstream/17613
Upstream sequence
ggtgatggaaatgttctggaattagagagtgatgatggcttcacaacactgtgaaaatcctaaaatccaccaaatgaaaaccattttaaagtggttaaaa
Downstream sequence
tggtaaattttgggctgggtgtggtggcgcatgcctgtaaacccagcactttgggaggctgaggctggggattgcttgaatcccggagtttgagaccagc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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