Basic Information
VIS ID
TVIS44001962
Fusion event
HTLV-1-CGGBP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
88128077/88078927 (Hg38)
End
88128077/88078927 (Hg38)
Orient
+
Location type
Intronic
Target gene
CGGBP1
miRNAs that regulate target gene
hsa-mir-96-5p ; hsa-mir-4709-3p ; hsa-mir-6867-3p ; hsa-mir-520f-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-3667-3p ; hsa-mir-5088-3p ; hsa-mir-4661-3p ; hsa-mir-186-5p ; hsa-mir-3133
Nearest miRNA
hsa-let-7g/Upstream/852650; hsa-mir-12124/Downstream/8281037;
Nearest TSS
ENST00000440867/Upstream/19653; ENST00000623596/Downstream/7393;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/20067, chr3-CpG: 70/Downstream/70437
Upstream sequence
ctgttgactaaagaatactgattaatggttctaaggatagctaaggaactgaacttggttctattataaattctctgtgaatttttttttgtatacaact
Downstream sequence
ttgatgataaaaaactaacttttcagatttataggtgacacaaactgggaggaaaagctaatgtattggctaaaaagtcagtgttgaaggtttgggctga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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