Basic Information
VIS ID
TVIS44001966
Fusion event
HTLV-1-BMP2K integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.21
Reference genome
GRCh37/hg19
Start
79787229/78866075 (Hg38)
End
79787229/78866075 (Hg38)
Orient
+
Location type
Intronic
Target gene
BMP2K
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-let-7e-5p ; hsa-mir-1228-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-6885-3p ; hsa-mir-6771-3p ; hsa-mir-1909-5p ; hsa-mir-4693-3p ; hsa-mir-551b-5p ; hsa-mir-4311 ; hsa-mir-548c-3p ; hsa-mir-4477a ; hsa-mir-508-5p ; hsa-mir-3145-5p ; hsa-mir-606 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-4672 ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-610 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-5697 ; hsa-mir-101-5p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a
Nearest miRNA
hsa-mir-12113/Upstream/2290449; hsa-mir-1243/Downstream/3887262;
Nearest TSS
ENST00000502981/Upstream/6451; ENST00000507670/Downstream/6253;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/89271, chr4-CpG: 68/Downstream/72984
Upstream sequence
TCTTATCCCTAGAGTCATCAACTAATAGGGTTTGAGGTTGGGAATAAAGTTCAACGGTATGGAAAAAGTCTATGTTATATGAGAAAGAAAGTTGAAACAC
Downstream sequence
TAGTCTTACAAAGTTTATGTCTTTGTATTGCACCTAGAGCCTTGGTGAAGGGCTATCTTGAACCATCCATATGGACATTACAACATAAAAACTTACCTGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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