Basic Information
VIS ID
TVIS44001993
Fusion event
HTLV-1-CCDC171 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
16040297/16040299 (Hg38)
End
16040297/16040299 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCDC171
miRNAs that regulate target gene
hsa-mir-6832-3p ; hsa-mir-4753-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-130b-5p ; hsa-mir-4282 ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-500a-3p ; hsa-mir-642a-5p ; hsa-mir-6804-3p ; hsa-mir-600 ; hsa-mir-3130-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-1306-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-875-5p
Nearest miRNA
hsa-mir-101-2/Upstream/10032395; hsa-let-7a-1/Downstream/2533007;
Nearest TSS
ENST00000422679/Upstream/152504; ENST00000478913/Downstream/2499;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/486963, chr9-CpG: 30/Downstream/686562
Nearby gene
CCDC171(No orient, 68400)
Upstream sequence
GGCATCGTGTTGGAGGCTGGCCAACGCTTTGCCCAGTCCTGCCTCTGTTCCTGGAGCCCCTCTTTCCTTATCTTGATCCCCCCACTTCTCCCTCCCACAC
Downstream sequence
CTCCCCAGTGAAGGGATTCTGCAGATTGATGGACTGTCATCTAGAAGGTGGAGGCAGACCTCAGATTCCTGAGTTCTTGAAGGAAAGGGATTAATGAGCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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