Basic Information
VIS ID
TVIS44001995
Fusion event
HTLV-1-CNKSR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.12
Reference genome
GRCh37/hg19
Start
21608587/21590469 (Hg38)
End
21608587/21590469 (Hg38)
Orient
-
Location type
Intronic
Target gene
CNKSR2
miRNAs that regulate target gene
hsa-mir-758-3p ; hsa-mir-6808-3p ; hsa-mir-4460 ; hsa-mir-7973 ; hsa-mir-5681b ; hsa-mir-6847-3p ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-4662a-3p ; hsa-let-7a-3p ; hsa-let-7b-3p ; hsa-let-7f-1-3p ; hsa-mir-2681-5p ; hsa-mir-300 ; hsa-mir-381-3p ; hsa-mir-4666a-3p ; hsa-mir-5580-3p ; hsa-mir-8063 ; hsa-mir-98-3p
Nearest miRNA
hsa-mir-23c/Upstream/1573282; hsa-let-7f-2/Downstream/6905086;
Nearest TSS
ENST00000429181/Upstream/52601; ENST00000647058/Downstream/4402;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/215179, chrX-CpG: 270/Downstream/65431
Upstream sequence
atatcctttcctgcttcacaggagattagaaagttaagtgacatgatgtatatgaatttgttttgAGGCTTTGTGGGGAAAAAGTTCTTCCCCTAACAGT
Downstream sequence
GTTTAGAGTCATCATTTAGCTCTTGAGAGTTCTGTGTAGCGTGCTGGTGCTCTGGATCACACCCTGAGTATCAGATAACATTCTTTTTATCTTTGATTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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