Basic Information
VIS ID
TVIS44002019
Fusion event
HTLV-1-ASTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
177096416/177127280 (Hg38)
End
177096416/177127280 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASTN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1273e ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3915 ; hsa-mir-1200 ; hsa-mir-7162-5p ; hsa-mir-378a-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-6804-5p ; hsa-mir-3928-3p ; hsa-mir-544b ; hsa-mir-4324
Nearest miRNA
hsa-mir-101-1/Upstream/97835; hsa-mir-1182/Downstream/1550469;
Nearest TSS
ENST00000473358/Upstream/94730; ENST00000460161/Downstream/37403;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/919605, chr1-CpG: 44/Downstream/36976
Upstream sequence
TAAGCTTCTCTGATAGttctgaaatttatttccattggcttacattcctgtatgtggaagactttagtgtcgattgcacactaaagaaatttcattatga
Downstream sequence
cctctctcttctataaaaatattaaaatgttaaattaaaaatttgaagtagtggtttctagaagaccccacggttaatgctttttattccgagaagcact
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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