Basic Information
VIS ID
TVIS44002020
Fusion event
HTLV-1-ADARB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
1543932/1501737 (Hg38)
End
1543932/1501737 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADARB2
miRNAs that regulate target gene
hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-144-5p ; hsa-mir-4795-5p ; hsa-mir-34c-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4295 ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3117-5p ; hsa-mir-6776-3p ; hsa-mir-4753-5p ; hsa-mir-6768-3p ; hsa-mir-497-3p ; hsa-mir-2681-5p
Nearest miRNA
hsa-mir-5699/Upstream/859959; hsa-mir-107/Downstream/574282;
Nearest TSS
ENST00000439456/Upstream/261207; ENST00000381301/Downstream/24900;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/26619, chr10-CpG: 29/Downstream/39605
Upstream sequence
ggcccaatcaaaacagctcgaatatattgctcgccagtagcctgttttgatccaagggtaaaatgtaaactagccaggggaatttatggacttcatgtcc
Downstream sequence
ttcagccaatcctccataaatatcatttctccccactgggcatttcaggaggattagaaaacagaattctttttttattcactgacaagaacctggaggg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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