Basic Information
VIS ID
TVIS44002024
Fusion event
HTLV-1-JAKMIP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
133853238/132039734 (Hg38)
End
133853238/132039734 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
JAKMIP3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3663-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-660-3p ; hsa-mir-1306-5p ; hsa-mir-1228-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6736-3p ; hsa-mir-149-3p ; hsa-mir-3141 ; hsa-mir-3153 ; hsa-mir-4728-5p ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-6768-3p ; hsa-mir-6783-5p ; hsa-mir-6785-5p ; hsa-mir-6883-5p
Nearest miRNA
hsa-mir-107/Upstream/1077066; hsa-mir-202/Downstream/1207777;
Nearest TSS
ENST00000439456/Upstream/57721; ENST00000298622/Downstream/64937;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2412, chr10-CpG: 24/Downstream/7907
Nearby gene
BNIP3(-57721) ;
Upstream sequence
GGCGACCCCCACTCCCTCCATAGCGCTGGGCTGTCAGACCAGTGAGGTCTGAAAATCTGGCTGGCCCCCGATTCCCTACAGCGGCATCCAGCAAAGGTCT
Downstream sequence
TGAAGATGGGGGAAGCTTCATTTCTGGCCTCCTCTCTCGGCCTCCAGCCGCTGTATTGACTTGGCTCTTACAGCCTCTCTGGGTTGCCCCCACCTCCACG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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