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TVIS44002028
Basic Information
VIS ID
TVIS44002028
Fusion event
HTLV-1-MYCBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
77645557/77071422 (Hg38)
End
77645557/77071422 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
MYCBP2
miRNAs that regulate target gene
hsa-mir-21-5p
;
hsa-mir-15b-5p
;
hsa-mir-183-5p
;
hsa-mir-148a-3p
;
hsa-mir-196a-5p
;
hsa-mir-17-5p
;
hsa-mir-377-3p
;
hsa-mir-487a-3p
;
hsa-mir-493-3p
;
hsa-mir-6083
;
hsa-mir-4795-3p
;
hsa-mir-496
;
hsa-mir-4742-3p
;
hsa-mir-126-5p
;
hsa-mir-606
;
hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1297/Upstream/10853098; hsa-mir-1267/Downstream/626590;
Nearest TSS
ENST00000623511/Upstream/13088;
ENST00000471491/Downstream/16092;
Nearest CpG islands
None/Target,
chr13-CpG: 551/Upstream/44129
,
chr13-CpG: 64/Downstream/254977
Upstream sequence
cttcgcaacaaccccagaaggtaaattgtaatattttgcctactttacaggtaagaaaactgaggtaagaaaCTCTTTTGTTTAAGAATCAAAAATGATG
Downstream sequence
CTTGgttttacatttcttaagatagagagccagaagagaatgtccctttcgccctaacaatgaggaaaaacctgatcatctacaaaaccaaaactttttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Sample Information
×
Sample name
ATL11-CR3
Sample type
Nontumor
Age
27
Gender
Male
CpG Island Information
×
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