Basic Information
VIS ID
TVIS44002048
Fusion event
HTLV-1-DPP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
154158979/154461894 (Hg38)
End
154158979/154461894 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
DPP6
miRNAs that regulate target gene
hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-4668-5p ; hsa-mir-3153 ; hsa-mir-513b-3p ; hsa-mir-1276 ; hsa-mir-497-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-511-5p ; hsa-mir-6830-3p
Nearest miRNA
hsa-mir-10399/Upstream/3028255; hsa-mir-153-2/Downstream/3112442;
Nearest TSS
ENST00000635602/Upstream/156452; ENST00000478614/Downstream/331700;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/156698, chr7-CpG: 22/Downstream/288455
Upstream sequence
tatttactccattctgtgggttgtcttttaactttgttgattgtttcctttgctgtgcattttaactcaatgtgattccaattgtccatttttgctttgg
Downstream sequence
ttgcctttgctaaatagggtattactcaagaaatttttacctagtacagtgtcctggagagtttccccaatttttttttaagtagtttcattgtttgagg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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