Basic Information
VIS ID
TVIS44002052
Fusion event
HTLV-1-SNTB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
121638813/120626573 (Hg38)
End
121638813/120626573 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
SNTB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-24-3p ; hsa-mir-5011-5p ; hsa-mir-218-5p ; hsa-mir-510-3p ; hsa-mir-3606-5p ; hsa-mir-1825 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-8062 ; hsa-mir-1277-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p
Nearest miRNA
hsa-mir-12123/Upstream/1301308; hsa-mir-10400/Downstream/2589215;
Nearest TSS
ENST00000518652/Upstream/87878; ENST00000509350/Downstream/67335;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/181156, chr8-CpG: 121/Downstream/184602
Upstream sequence
atatgcatagggagatgaaaaatagagtaaatgtttatttagtaatctctaatttaaaacattagaagaattgaggattaaagtgaagagtagtttgaat
Downstream sequence
agacctttttgtcttctcctcatctaacttataatatagaacaagcttttttttttaatgctttgacaaattgtcatcatcctttctaagtttggatcag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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