Basic Information
VIS ID
TVIS44002061
Fusion event
HTLV-1-PRMT6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
107601207/107058585 (Hg38)
End
107601207/107058585 (Hg38)
Orient
+
Location type
UTR3
Target gene
PRMT6
miRNAs that regulate target gene
hsa-mir-6505-3p ; hsa-mir-4330 ; hsa-mir-617 ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-6895-5p
Nearest miRNA
hsa-mir-101-1/Upstream/6777277; hsa-mir-11399/Downstream/838638;
Nearest TSS
ENST00000473358/Upstream/1906; ENST00000370076/Downstream/81422;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/797, chr1-CpG: 18/Downstream/81682
Upstream sequence
CACATTAATCCGTTAAGTAAAATGGACTTTGTAATTGTACAGCATACCTAAGAAACTCAGAAGGTGCATTTAAGAGAGAGACCTGAAAGAAATAGTATGG
Downstream sequence
ATTTTTAAAAATTCTTGTCTCTACTATTATAACCAAAAAATATTTCTTGTATGTCCCATAAAAATATTTGTGTAATTCTTATGAAACAGGCTGGTAGAGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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