Basic Information
VIS ID
TVIS44002086
Fusion event
HTLV-1-SGMS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
108747172/107826016 (Hg38)
End
108747172/107826016 (Hg38)
Orient
+
Location type
Intronic
Target gene
SGMS2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-mir-190a-5p ; hsa-mir-190b ; hsa-mir-548t-5p ; hsa-mir-3609 ; hsa-mir-3613-3p ; hsa-mir-3689a-5p ; hsa-mir-3689b-5p ; hsa-mir-548ah-5p ; hsa-mir-3689e ; hsa-mir-3689f ; hsa-mir-548az-5p ; hsa-mir-133a-3p ; hsa-mir-6741-5p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-6766-5p ; hsa-mir-6745 ; hsa-mir-6756-5p ; hsa-mir-363-5p ; hsa-mir-885-3p ; hsa-mir-7852-3p ; hsa-mir-3668
Nearest miRNA
hsa-mir-12113/Upstream/6495602; hsa-mir-1243/Downstream/1662682;
Nearest TSS
ENST00000502981/Upstream/808; ENST00000506993/Downstream/67222;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/637, chr4-CpG: 99/Downstream/105323
Upstream sequence
TGCTCTGAAATGACCTTAAAATCATTTTGACATGTGTGTTATATTTTGAAGAGATTCAACTGTTTAGTGTCACTGGATTCGGCGTGGGTTTTCAATCTGT
Downstream sequence
ACCTAACTTttcaaatccttggtttcattaccagtctcctctattaacggtgggtgctcaggcacattaaacattctgaaccagtaaaatgggattatag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate