Basic Information
VIS ID
TVIS44002095
Fusion event
HTLV-1-LRRC8C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
90137819/89672260 (Hg38)
End
90137819/89672260 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
LRRC8C
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3314573; hsa-mir-11399/Downstream/4174572;
Nearest TSS
ENST00000473358/Upstream/39079; ENST00000416805/Downstream/91285;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/38527, chr1-CpG: 30/Downstream/90925
Upstream sequence
atgttctcctggccttggcctccaattttacctagctaactgttactacttatactatacttcatacttccatgcaagcatcacttcctaaacccccagt
Downstream sequence
agttcaggtcctaacatatactgtcagagtgacctacacttctacttcatcatgcttgtcacaattgtgattaaatggttgtgtgtcattgtttactgtc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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