Basic Information
VIS ID
TVIS44002098
Fusion event
HTLV-1-PLXNA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
208375707/208202362 (Hg38)
End
208375707/208202362 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLXNA2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-3202 ; hsa-mir-6878-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-5189-3p ; hsa-mir-1253 ; hsa-mir-6754-5p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-6760-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p ; hsa-mir-7977 ; hsa-mir-601 ; hsa-mir-3663-5p ; hsa-mir-6131 ; hsa-mir-338-3p ; hsa-mir-103b ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6716-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-6845-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-6892-3p ; hsa-mir-4717-3p
Nearest miRNA
hsa-mir-101-1/Upstream/399839; hsa-mir-1182/Downstream/1229771;
Nearest TSS
ENST00000473358/Upstream/162098; ENST00000415754/Downstream/14652;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/238524, chr1-CpG: 122/Downstream/40782
Upstream sequence
agccaccatacctggccagggcagccatttttgacagttttattttctactgctttataccaagctcctggcacacagtacatattcaataaatatcagt
Downstream sequence
tcaataatgaattatgtcatttaatccttactgtaatcttatgatgccggtaccagaactgtcctcattttacattgaggaaattaaagctcagaggtca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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