Basic Information
VIS ID
TVIS44002102
Fusion event
HTLV-1-NADSYN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71187029/71475983 (Hg38)
End
71187029/71475983 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
NADSYN1
miRNAs that regulate target gene
hsa-mir-7856-5p ; hsa-mir-5004-3p ; hsa-mir-4503 ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4320 ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-6849-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p
Nearest miRNA
hsa-mir-10392/Upstream/2415; hsa-let-7a-2/Downstream/596245;
Nearest TSS
ENST00000527297/Upstream/1588; ENST00000527227/Downstream/2412;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22349, chr11-CpG: 27/Downstream/42958
Upstream sequence
gtatttacttagtagagacagggtttcactgtgttgccccggctggtcgcaaactcctgagctcaggcaatccacgcacctcagcctcccaaagtgctgg
Downstream sequence
gattacaggtgtgagccaccgcacccggcctctctttctgtttttgaagcaaacaagaaaaaatgggctattattgccacaaatggaaacaaatcccaag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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