Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene171443327170990823171231314171165847171167697171210339171211600171185613171186674171173086171173438171212111171212260171212451171212600171217075
Basic Information
VIS ID
TVIS44002119
Fusion event
HTLV-1-TLK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
172073585/171217075 (Hg38)
End
172073585/171217075 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
TLK1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-28-5p ; hsa-mir-374b-3p ; hsa-mir-5696 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-1909-5p ; hsa-mir-4729 ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-646 ; hsa-mir-5586-3p ; hsa-mir-503-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-1305 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-4660 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-4801 ; hsa-mir-4731-3p
Nearest miRNA
hsa-mir-128-1/Upstream/2634057; hsa-mir-10b/Downstream/3950558;
Nearest TSS
ENST00000437798/Upstream/56175; ENST00000495925/Downstream/14239;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/55725, chr2-CpG: 104/Downstream/216779
Upstream sequence
ttctgttattttaagccactcagtgtgtagcacttttttacggcagccctaggaaactgatacCAAACTGATGCATTTATCCTCCCTACTTTTTCACTGT
Downstream sequence
TACCTCCTACCTTCCAACAGCAGTGCCACAGAACAGGAGTCCCACTTGTTAGGGAAAGAAACAAAAACCTGAGTTATTCATTCATTcagagcctggcatg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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