Basic Information
VIS ID
TVIS44002129
Fusion event
HTLV-1-CPNE4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
131680583/131961739 (Hg38)
End
131680583/131961739 (Hg38)
Orient
-
Location type
Intronic
Target gene
CPNE4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-122-5p
Nearest miRNA
hsa-let-7g/Upstream/2689496; hsa-mir-1224/Downstream/24116;
Nearest TSS
ENST00000440867/Upstream/36158; ENST00000483689/Downstream/56016;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/434562, chr3-CpG: 25/Downstream/73297
Upstream sequence
CTATCCCTGCTCTGTTGTCTATTCCTGACTCTTAAGATCCACACCTAGAGGACTAAAGATAGAACATACAGGATTGAAGGGGGCTCATGGTCCCACATTA
Downstream sequence
CAATCCTCAAAAAATGACCTTAAAGACAGACTAGCAGGTGAAAGGGTAGAGACAACATAGGTGACATCACCAAGAGTCACACATACCAAATATCAAAAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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