Basic Information
VIS ID
TVIS44002137
Fusion event
HTLV-1-DNAH5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
13886604/13886495 (Hg38)
End
13886604/13886495 (Hg38)
Orient
-
Location type
Intronic
Target gene
DNAH5
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-10397/Upstream/3408350; hsa-mir-103a-1/Downstream/939434;
Nearest TSS
ENST00000502646/Upstream/26157; ENST00000505971/Downstream/45961;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/76271, chr5-CpG: 48/Downstream/125015
Upstream sequence
CCATCAGCAGCCTCTCTACTCGTCACATTTCCTTCATATCACATAAATCGGATCCAGCCACCCTTCTTTCTCTCCTTGTTTTTGCCAACAAACCATAGTC
Downstream sequence
ATCCCCTCATTAATTTCAAAGACACTACCCACCCTTCTAACTATATTGTGCATTTCTCAAGAATGGATTTAATAAATATAAACTAACATGATTTGAGGCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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