VISDB Viral Integration Site DataBase

VIS ID

TVIS44002145

Fusion event

HTLV-1-TRIB1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr8

Cytoband

q24.13

Reference genome

Start

End

126444905/125432663 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA8C ; FRA8E

Target gene

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-335-5p ; hsa-mir-99a-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-224-5p ; hsa-mir-3658 ; hsa-mir-5006-5p ; hsa-mir-3653-3p ; hsa-mir-4694-5p ; hsa-mir-4755-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-6507-5p ; hsa-mir-3934-5p ; hsa-let-7c-3p ; hsa-mir-331-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-3163 ; hsa-mir-4678 ; hsa-mir-1277-5p ; hsa-mir-548m ; hsa-mir-887-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-30b-3p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-4425 ; hsa-mir-4303 ; hsa-mir-8085 ; hsa-mir-6878-5p ; hsa-mir-6731-5p ; hsa-mir-3670 ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-4653-5p ; hsa-mir-4766-5p ; hsa-mir-3921 ; hsa-mir-1306-3p ; hsa-mir-759 ; hsa-mir-148b-5p ; hsa-mir-6874-3p ; hsa-mir-6854-5p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-6749-3p ; hsa-mir-642a-5p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-942-5p ; hsa-mir-4469 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-877-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-100-5p ; hsa-mir-101-3p ; hsa-mir-1287-3p ; hsa-mir-144-3p ; hsa-mir-4426 ; hsa-mir-449b-3p ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-99b-5p

Nearest miRNA

hsa-mir-12123/Upstream/610605; hsa-mir-10400/Downstream/2363299;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/465, chr8-CpG: 180/Downstream/1123768

Nearest cancer related gene

TRIB1(OG, No orient, 0)

Upstream sequence

GAGACCAGCCAGCTTCCTAGAAGAGAGGAGATGCTACTCATTTCTAGGGGTGGGGTCGGGTGTGGGGGGATAAACAAACAAGTGGAAAACCCATTCGCAG

Downstream sequence

GATTCCATACCCTTCCTGTGAGAATTGTAACTCAAGGCTGCTTACACTTGAGTCGGACTGTAGGCAGGTTGCTTAAGGCTGCATTGTCCCAGCCTCCCCC