Basic Information
VIS ID
TVIS44002147
Fusion event
HTLV-1-PRUNE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
79304464/76689548 (Hg38)
End
79304464/76689548 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRUNE2
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-196a-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-769-5p ; hsa-mir-382-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-4671-3p ; hsa-mir-593-5p ; hsa-mir-6124 ; hsa-mir-4733-3p ; hsa-mir-3148 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-4796-3p ; hsa-mir-548m ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-130a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/5879464; hsa-let-7a-1/Downstream/7280200;
Nearest TSS
ENST00000422679/Upstream/36999; ENST00000645839/Downstream/2432;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/229903, chr9-CpG: 75/Downstream/216339
Upstream sequence
gggctcaaggcatcctcctgcctcagcctcccaagcagctggaactacaggtgcatgccaccacattcagctaattttaaaattttctatagagacaggg
Downstream sequence
tctctatagagaccagctcaggctggtctcaaacttctggtctcaagtgatcctcctgcctcagcctcccaaagtgctgggattgcagccatgagatacc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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