Basic Information
VIS ID
TVIS44002155
Fusion event
HTLV-1-TP53BP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
224013549/223825847 (Hg38)
End
224013549/223825847 (Hg38)
Orient
+
Location type
Intronic
Target gene
TP53BP2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-1301-3p ; hsa-mir-877-3p ; hsa-mir-222-3p ; hsa-mir-548d-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3625228; hsa-mir-1182/Downstream/431193;
Nearest TSS
ENST00000473358/Upstream/4711; ENST00000618397/Downstream/222;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/76505, chr1-CpG: 138/Downstream/19536
Nearest cancer related gene
TP53BP2(TSG, No orient, 0)
Upstream sequence
CAAAGAGAGAGAAAGAAAGCTGTTAGAAGGACACAGCcagcccacaggaaggaagtcaaaaaaataaacaccacaacctggctccttccctctcatgtcc
Downstream sequence
acccactactccccactggacaaacccaactacctaccagatggcaagggaagcggttgatgcagtttagagaagtcaacctcctaaggcacaaagcagg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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