Basic Information
VIS ID
TVIS44002168
Fusion event
HTLV-1-SUDS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
118840269/118402464 (Hg38)
End
118840269/118402464 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
SUDS3
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-99a-5p
Nearest miRNA
hsa-let-7i/Upstream/1974146; hsa-mir-1178/Downstream/1311170;
Nearest TSS
ENST00000382841/Upstream/231; ENST00000360286/Downstream/1037;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/25430, chr12-CpG: 29/Downstream/371841
Upstream sequence
CCTAGGCAGTTCTGCTCCCGTGGCTTTTCGTGGCCTGACTCTGGTAAGGCATTCCAAGGCTGCTCTGACTCGCAGTTCATAGAAGAGACCAACCAGCTCA
Downstream sequence
GTATTCATAGTTGTTCCTTCCGGAACAGCACTTGAGATCATCAGTGCTAGCTGCCAACTAGAATTCTGAATTGGTGACATCTTTTTTTTGTTTAAAGCAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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