Basic Information
VIS ID
TVIS44002173
Fusion event
HTLV-1-SIRT4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
120731669/120293866 (Hg38)
End
120731669/120293866 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
SIRT4
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-148b-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-15b-3p
Nearest miRNA
hsa-let-7i/Upstream/138367; hsa-mir-3612/Downstream/429327;
Nearest TSS
ENST00000382841/Upstream/28095; ENST00000536460/Downstream/8450;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28128, chr12-CpG: 26/Downstream/23677
Nearby gene
SIRT4(+8455) ;
Nearest cancer related gene
SIRT4(TSG, No orient, 0)
Upstream sequence
taaacccttactccctgttcccttctcctccagcccccgtggcaacctcttttctactttctatctctatgactttgtgagtactttatatatatataaa
Downstream sequence
tggaatcatacaatatttgtccttgaggtcagtcttatttcattcagaataatgtttttaaggttcatccatgttgtagtatatatcaggaattcattaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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