Basic Information
VIS ID
TVIS44002181
Fusion event
HTLV-1-MTHFSD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
86564626/86531020 (Hg38)
End
86564626/86531020 (Hg38)
Orient
+
Location type
UTR3
Target gene
MTHFSD
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-92a-3p ; hsa-mir-4531 ; hsa-mir-3151-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-185-3p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-4656 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-6770-5p ; hsa-mir-3179 ; hsa-mir-6754-5p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-3154
Nearest miRNA
hsa-mir-12128/Upstream/612604; hsa-mir-11401/Downstream/1303572;
Nearest TSS
ENST00000527434/Upstream/7123; ENST00000320354/Downstream/2780;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/14114, chr16-CpG: 41/Downstream/731
Upstream sequence
TTTCTTTGCGAAGTCTCCACAGGATTTTCACGGCAAAACCAATGAGAAAATGTCCTTTCAAAGAGAAGACCGAGTGTCCCGAGAACATTTTCTTGAAAGC
Downstream sequence
GCGTGCACGGGCCGCCCTCTCGAGGCATCGTAATGTGCTTCAAAGAACACTTGGTAAAACCCTCTGGCTAAAAAATCAAAATTTCCAAAGCATATACATT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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