Basic Information
VIS ID
TVIS44002183
Fusion event
HTLV-1-NOD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
50730426/50696515 (Hg38)
End
50730426/50696515 (Hg38)
Orient
+
Location type
Intronic
Target gene
NOD2
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-122-5p ; hsa-mir-10a-5p ; hsa-mir-320a ; hsa-mir-320b ; hsa-mir-320c
Nearest miRNA
hsa-mir-1225/Upstream/403840; hsa-mir-11401/Downstream/45790;
Nearest TSS
ENST00000527434/Upstream/2889; ENST00000527070/Downstream/624;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/22385, chr16-CpG: 110/Downstream/45199
Nearby gene
NOD2(+624) ;
Upstream sequence
GTAGAGATCAAAAGGCAATGCAGATAGACTGACAGATTTCGCCTGAAGAGGGGAAGCCCGACCAGGTAATAAAGGAGTAAGAGGAAGGATGTTAAGGACA
Downstream sequence
ATTTTAGGAAACAGATAATGAGTGAATATTTTTTCTCTCTCTTTCCCAATTTAAACTGAAGCAGGAGAAACTGAAGCTAGACATAATGATTAACTTCCCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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