Basic Information
VIS ID
TVIS44002197
Fusion event
HTLV-1-PARP14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
122449341/122730494 (Hg38)
End
122449341/122730494 (Hg38)
Orient
+
Location type
UTR3
Target gene
PARP14
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-let-7g/Upstream/1680779; hsa-mir-12124/Downstream/431300;
Nearest TSS
ENST00000440867/Upstream/12110; ENST00000477647/Downstream/11282;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/49151, chr3-CpG: 28/Downstream/63144
Upstream sequence
CAATGCAGATAGCACATCAGATGCTAGGGGTCGCTGGGAGGATTAAGGGACTTAATCTGCTAGGAACACCTGTACTTGAAGTGGAGGAGGCTAGGGGGCC
Downstream sequence
ACAGTTGCTGCTTCATTAACATAGAGGTTTTGGATTTTTTTCTCTTGTGGTTTGTTTTTTAAGTGGATTGGCAGACTCCTTGTTGCTTAAGAGTGGCTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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