Basic Information
VIS ID
TVIS44002221
Fusion event
HTLV-1-SNTG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
51203160/50290600 (Hg38)
End
51203160/50290600 (Hg38)
Orient
+
Location type
Intronic
Target gene
SNTG1
miRNAs that regulate target gene
hsa-mir-2681-5p ; hsa-mir-548c-3p ; hsa-mir-7977 ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-3671 ; hsa-mir-6849-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-124-1/Upstream/7394325; hsa-mir-10400/Downstream/11424188;
Nearest TSS
ENST00000518652/Upstream/118039; ENST00000524004/Downstream/262450;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/380300, chr8-CpG: 98/Downstream/1118002
Upstream sequence
GGAAAGTCCAGTCTTTGGCAAATACCTAATACTTTTAGTTTGCAGTTTCCGAAGAGTTTTAGGTTTTTCCAGTTGTAATATCCTTGATTCCTAAATATAG
Downstream sequence
TCATTAGTATAGCACATATATTACTTTATTGTCCTTATTTATTTACATTTGCTTATTCCTATTCATTCTTCTTGAGGACAAAATCTAGTCAGTTATCATA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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