Basic Information
VIS ID
TVIS44002240
Fusion event
HTLV-1-VTI1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
114604165/112844406 (Hg38)
End
114604165/112844406 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
VTI1A
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-18b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-6891-3p ; hsa-mir-452-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-302a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-205-5p ; hsa-mir-6793-3p ; hsa-mir-532-5p ; hsa-mir-141-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/210152; hsa-mir-202/Downstream/933587;
Nearest TSS
ENST00000439456/Upstream/166587; ENST00000346198/Downstream/105844;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/396844, chr10-CpG: 34/Downstream/105484
Nearby gene
LOC103344931(No orient, 16674)
Upstream sequence
CAAATCTCCATCTTAACTTCCAAACTTGAGTTGAGAACCAAACATGAAGCCTGGATCTTTTCATTATGAGAGGCTCTGAGGTCATGGAAAGGAGAAGGGG
Downstream sequence
ACGATAAAGCCAagacggagtcttgctctgtcgccctggctggagtcagtggttcaatctcggctcactgcaatctccacctcccgggttgaagcgattc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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