Basic Information
VIS ID
TVIS44002241
Fusion event
HTLV-1-GDI2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
5814559/5772596 (Hg38)
End
5814559/5772596 (Hg38)
Orient
-
Location type
Intronic
Target gene
GDI2
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-193b-3p ; hsa-mir-328-3p ; hsa-mir-222-3p ; hsa-mir-30c-5p ; hsa-mir-20a-5p ; hsa-mir-15a-5p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426
Nearest miRNA
hsa-mir-5699/Upstream/1781337; hsa-mir-107/Downstream/379600;
Nearest TSS
ENST00000439456/Upstream/3207; ENST00000608273/Downstream/13326;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/86862, chr10-CpG: 132/Downstream/40147
Upstream sequence
ctgtaatcccaacactttgggaggctgaggcgggcggatcacttggggccgggagttcgagaccagcctggccaacatggtgaaaccccatctctactaa
Downstream sequence
aaatacataaattagccaggcatggtggcatgcatctgtaattccagctactcgggaggctgaggtaggagaatcacttgaacctggaaggtggagggtg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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