Basic Information
VIS ID
TVIS44002242
Fusion event
HTLV-1-NEBL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.31
Reference genome
GRCh37/hg19
Start
21389170/21100241 (Hg38)
End
21389170/21100241 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEBL
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-4684-5p ; hsa-mir-6892-5p ; hsa-mir-942-5p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-6507-3p ; hsa-mir-6883-3p ; hsa-mir-3156-3p ; hsa-mir-324-5p ; hsa-mir-3162-3p ; hsa-mir-4301 ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-1265/Upstream/548195; hsa-mir-107/Downstream/396321;
Nearest TSS
ENST00000439456/Upstream/200550; ENST00000417845/Downstream/46318;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1282224, chr10-CpG: 149/Downstream/72958
Upstream sequence
TCTATTGACTCTTTAGTTTCCCTAATTAACCTCTGCTGCTGTGATCACCCCCTTTTAATTCTCTTGGCGAGCATTTACTAAGCGTGTGTGGGATGTGTGG
Downstream sequence
TACCCGACCATTCCCCACCATCAGCCGGTCCTTTTCCACGCTGTGCTGTTGACTGTGTTTCTTTCATCCCACTTGCCTTTTCTTTCTTTATTCCCTCTCG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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