Basic Information
VIS ID
TVIS44002259
Fusion event
HTLV-1-MBNL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
97906522/97254268 (Hg38)
End
97906522/97254268 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
MBNL2
miRNAs that regulate target gene
hsa-mir-372-3p ; hsa-mir-302d-3p ; hsa-mir-218-5p ; hsa-mir-335-5p ; hsa-mir-101-3p ; hsa-mir-98-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-5011-5p ; hsa-mir-369-3p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-5583-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-410-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-10b-5p
Nearest miRNA
hsa-mir-1297/Upstream/826976; hsa-mir-1267/Downstream/954256;
Nearest TSS
ENST00000623511/Upstream/31913; ENST00000449284/Downstream/102528;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/259785, chr13-CpG: 34/Downstream/92440
Upstream sequence
aagccaccatgcccagccCAATGCaaatttttaaaatatgtaaaattttaactattaaatGCTGCTGAGTAAGAAGCATTTAGATATTTAGATTAAAATG
Downstream sequence
TTATAACACTGAATAGTTTCCAAATGTGAAATGTTAATATTTCTTTCTCTTTGAAAAATAAACTATAACTTACACATAAAAATCTAAAATATAATTATTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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