Basic Information
VIS ID
TVIS44002260
Fusion event
HTLV-1-MYO16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
109811003/109158655 (Hg38)
End
109811003/109158655 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYO16
miRNAs that regulate target gene
hsa-mir-4695-3p ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-548b-3p ; hsa-mir-3133
Nearest miRNA
hsa-mir-1267/Upstream/1627407; hsa-mir-4502/Downstream/1182303;
Nearest TSS
ENST00000623511/Upstream/56736; ENST00000618966/Downstream/42828;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/17304, chr13-CpG: 604/Downstream/623611
Upstream sequence
TGCCTTTGTAGTCTCATCCAGTGACCTCACACCTATTTCTCCTCCCGCCTGTGAATTACTCAAAGGTAAAGATTTCATCATGTAGATTATGGCTAGAGGC
Downstream sequence
TCTATGCCTGAGACCCATTTTGGTTTTTGTCCAGAGATTGAAGCATATGCAATTGGGGAAAGGTGAGCttttttaaaaaaataataataaaGATGAAAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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