Basic Information
VIS ID
TVIS44002265
Fusion event
HTLV-1-ANGEL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77273972/76807629 (Hg38)
End
77273972/76807629 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANGEL1
miRNAs that regulate target gene
hsa-mir-1225-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-5695 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-3691-3p ; hsa-mir-5697 ; hsa-mir-562 ; hsa-mir-3611 ; hsa-mir-2110 ; hsa-mir-328-3p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6851-3p ; hsa-mir-6775-3p ; hsa-mir-1291 ; hsa-mir-671-5p ; hsa-mir-661 ; hsa-mir-5681a ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-4469 ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-6852-5p ; hsa-mir-6780b-3p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p ; hsa-mir-6757-5p ; hsa-mir-9500
Nearest miRNA
hsa-mir-208a/Upstream/2327425; hsa-mir-1185-1/Downstream/458589;
Nearest TSS
ENST00000550708/Upstream/1114; ENST00000555189/Downstream/4939;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/31363, chr14-CpG: 76/Downstream/4601
Upstream sequence
CTCCAGAGTGCTGGAATGTGACCCCCACCCTCTAGGAGCAGGTCCTGAGGCCAGGTGGGAAGCTGCTGGGTCACACTGAAACTTCCCAGAGTCACCAACA
Downstream sequence
GCAAGAACAGGCCCAGACTTAAGCTGAAGAGATTAGAGATGTGCACTGGATTTTCCTGCTCCTTGAATCCCTCAAGCCTCCCTTCCTGCATAAAGGTGCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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