Basic Information
VIS ID
TVIS44002269
Fusion event
HTLV-1-SYNE3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.13
Reference genome
GRCh37/hg19
Start
95944209/95477872 (Hg38)
End
95944209/95477872 (Hg38)
Orient
-
Location type
Intronic
Target gene
SYNE3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-132-3p ; hsa-mir-328-3p
Nearest miRNA
hsa-mir-1260a/Upstream/339886; hsa-mir-1185-1/Downstream/4631547;
Nearest TSS
ENST00000550708/Upstream/2036; ENST00000554161/Downstream/38264;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/117268, chr14-CpG: 100/Downstream/38289
Nearby gene
SYNE3(No orient, 2036)
Upstream sequence
CCCTGTAGCCACTCCCTGCCTTTGAATGCTTTACTTGAAAAGTGCATTGGATGTGCAAGCATTTAAATGTATTTGTTGTGGCTCTAATTTCTCAGCTAGT
Downstream sequence
GTGTGACTTGAATGGCTTCCAAAAACTCAGCTTTTATTTTTATTAAGCAAAGAATGGGAGGGACAGAGACGAGTCCTGCTGAGTCTCAGATGACAGGACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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