Basic Information
VIS ID
TVIS44002287
Fusion event
HTLV-1-TEKT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
15218952/15315635 (Hg38)
End
15218952/15315635 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA17A
Target gene
TEKT3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1253/Upstream/63939; hsa-mir-10226/Downstream/966379;
Nearest TSS
ENST00000595228/Upstream/6772; ENST00000584540/Downstream/15979;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/52446, chr17-CpG: 36/Downstream/25753
Upstream sequence
tatggtttgaagatagaaccaagagaatctcctatgaaattgaacaccagtgagaaaaaaaaaaaaaaaagagcttgagtcgttggaataatggaattcc
Downstream sequence
atcaactaagatagggggttggctggggagggagaagctaggggagaagatggaagttcagttgacatagtaaacttgagtgttcactgaacatctacat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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