Basic Information
VIS ID
TVIS44002291
Fusion event
HTLV-1-SMURF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
62619356/64623238 (Hg38)
End
62619356/64623238 (Hg38)
Orient
-
Location type
Intronic
Target gene
SMURF2
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-630 ; hsa-mir-511-5p ; hsa-mir-203a-3p ; hsa-mir-4670-3p ; hsa-mir-93-3p ; hsa-mir-382-5p ; hsa-mir-431-5p ; hsa-mir-526b-5p ; hsa-mir-4635 ; hsa-mir-665 ; hsa-mir-4495 ; hsa-mir-3667-5p ; hsa-mir-6807-5p ; hsa-mir-6872-3p ; hsa-mir-378a-5p ; hsa-mir-4454 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-186-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p
Nearest miRNA
hsa-mir-10226/Upstream/121925; hsa-mir-1250/Downstream/157521;
Nearest TSS
ENST00000595228/Upstream/24793; ENST00000577938/Downstream/37624;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/115790, chr17-CpG: 112/Downstream/38053
Upstream sequence
tggcctcagaattagtcatttctccaagcaaccctagGAATTACCAAATTTAAACATCCATAAAGACCCAAAATTTTCAAATATAAACAGTTGAGCCAAT
Downstream sequence
GAACCCTTCAGCTCCTAAGgtctaccttcactagatcattaagttccatgatatcaagaacttaactttgatctccactgtatacccagagtctagaaaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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