Basic Information
VIS ID
TVIS44002298
Fusion event
HTLV-1-FAM117B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
203520738/202656015 (Hg38)
End
203520738/202656015 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
FAM117B
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-186-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-489-3p ; hsa-mir-3913-3p ; hsa-mir-5692a ; hsa-mir-6771-3p ; hsa-mir-5011-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4455 ; hsa-mir-3650 ; hsa-mir-6747-5p ; hsa-mir-4772-5p ; hsa-mir-6798-5p ; hsa-mir-6782-5p ; hsa-mir-4668-5p ; hsa-mir-6772-3p ; hsa-mir-4448 ; hsa-mir-4268 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-3133 ; hsa-mir-216b-5p ; hsa-mir-216a-5p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-340-3p ; hsa-mir-4738-3p ; hsa-mir-508-5p ; hsa-mir-5189-5p ; hsa-mir-5586-3p ; hsa-mir-612 ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6827-3p ; hsa-mir-6849-3p ; hsa-mir-6860 ; hsa-mir-766-3p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-10b/Upstream/13522904; hsa-mir-1244-1/Downstream/4127219;
Nearest TSS
ENST00000437798/Upstream/20526; ENST00000430899/Downstream/164006;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/20125, chr2-CpG: 35/Downstream/118189
Upstream sequence
tataaattcagcttatttaatagatacaggactattaggttatctcttttttgaggaatgagctttggtagattgtgtctttcaaggaattggtttattt
Downstream sequence
gtggacatgcagttgtggtatttcattattcatctgtggagtttgtagtggtggcatcctttcggtcattcctgatttgaatatttgtatattttctctt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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