Basic Information
VIS ID
TVIS44002314
Fusion event
HTLV-1-GTF2IP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
14823899/13451578 (Hg38)
End
14823899/13451578 (Hg38)
Orient
-
Location type
Intronic
Target gene
GTF2IP2
Nearest miRNA
hsa-mir-10396a/Upstream/45118; hsa-let-7c/Downstream/193197;
Nearest TSS
ENST00000624081/Upstream/146426; ENST00000427446/Downstream/94455;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2823854, chr21-CpG: 39/Downstream/158037
Nearby gene
MIR3156-3(-45118) ;
Upstream sequence
AACTATATTAACATAAGCTGAATATTCAAATTTGTATGAATAAACCATTGATGGGCATGGAGGGAGAAAGCACCTCACCTATTAATAATAAATGAAATCC
Downstream sequence
CAGCTGTGTTCTCCAAAATCCATTTCAGGGTTGCAAGATCATAGTTCTCAGGGTGTTTAAAGGCAACACCTTCCGGAAGCCCCTGTACTATCAAAGCTGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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