Basic Information
VIS ID
TVIS44002315
Fusion event
HTLV-1-CYTH4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
37680124/37284083 (Hg38)
End
37680124/37284083 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
CYTH4
miRNAs that regulate target gene
hsa-mir-331-3p
Nearest miRNA
hsa-mir-1286/Upstream/997176; hsa-let-7a-3/Downstream/560189;
Nearest TSS
ENST00000624155/Upstream/1552; ENST00000467664/Downstream/8061;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/24284, chr22-CpG: 53/Downstream/40595
Upstream sequence
tctccatgttgcagataaggaaactgaggctcccagaggtgaactagagacggggactgacttgcttgaggtcacacggccagtcagcagcagagcaggg
Downstream sequence
acgagaaccTGCGGGAGAGAGCCCCAGGTTGGCCGGGGCTATGGAGAGGGCAGGGGAGGGGAGTCTCTGCTTTGCTTCAGCCGGTACTAGGGAGGAAATG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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