Basic Information
VIS ID
TVIS44002324
Fusion event
HTLV-1-BMPR1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
95693858/94772707 (Hg38)
End
95693858/94772707 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
BMPR1B
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-let-7a-5p ; hsa-mir-22-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4705 ; hsa-mir-4668-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-12113/Upstream/7472124; hsa-mir-1243/Downstream/4224680;
Nearest TSS
ENST00000502981/Upstream/14739; ENST00000502683/Downstream/223089;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/14049, chr4-CpG: 20/Downstream/775598
Upstream sequence
TGCAAAAATGTAATAAGATATAGTATAATTTGTAACAAATAGAAAGCTTCCTTAGTGACTCCTTAGATTCCAAAATATAATTTTTCCATTATGGAAAATT
Downstream sequence
ATATTTATGTTGAACATAAATAATCAGATGTTTGCTTCACTAATGATCCAGCTTATTTTaaaattatgttactggatttaacgatgtgacctctgttctg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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