Basic Information
VIS ID
TVIS44002333
Fusion event
HTLV-1-CDH12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
22651771/22651662 (Hg38)
End
22651771/22651662 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5E
Target gene
CDH12
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-759 ; hsa-mir-4433a-5p ; hsa-mir-4433b-5p ; hsa-mir-4646-3p
Nearest miRNA
hsa-mir-10397/Upstream/5495670; hsa-mir-103a-1/Downstream/9284440;
Nearest TSS
ENST00000502646/Upstream/12668; ENST00000507674/Downstream/201679;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1191919, chr5-CpG: 68/Downstream/2538732
Upstream sequence
acttccatgatcaaattaccaccacctggtctctctcccttgacacatggggattatgaggattacaattcaagataagatttgggtggagacacaaagc
Downstream sequence
ctaaccatatcaGCTAAggagtagttgataggatggtggttttttttttttcagagtaataaaatgttctaaaattgattgtcatgatggatgcacaaag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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