Basic Information
VIS ID
TVIS44002338
Fusion event
HTLV-1-RUNX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
45387944/45420207 (Hg38)
End
45387944/45420207 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
RUNX2
miRNAs that regulate target gene
hsa-mir-135b-5p ; hsa-mir-155-5p ; hsa-mir-335-5p ; hsa-mir-203a-3p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-204-5p ; hsa-mir-433-3p ; hsa-mir-338-3p ; hsa-mir-124-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-505-5p ; hsa-mir-484 ; hsa-mir-30b-5p ; hsa-mir-218-5p ; hsa-mir-23b-3p ; hsa-mir-34c-5p ; hsa-mir-30c-5p ; hsa-mir-205-5p ; hsa-mir-320a ; hsa-mir-135a-5p ; hsa-mir-222-3p ; hsa-mir-221-5p ; hsa-mir-628-3p ; hsa-mir-103a-3p ; hsa-mir-30a-3p ; hsa-mir-376c-3p
Nearest miRNA
hsa-mir-10398/Upstream/222437; hsa-mir-10524/Downstream/6724142;
Nearest TSS
ENST00000381078/Upstream/42254; ENST00000625924/Downstream/1798;
Nearest CpG islands
chr6-CpG: 60/Target, None/Upstream, None/Downstream
Nearest cancer related gene
RUNX2(TSG, No orient, 0)
Upstream sequence
CCTCGAGAGCGCACACCTGGCTACCCCGCACCCCCACCTCTGCTCCCGCGGTCTGGCAGACCCTCAGTCCCCCGCGCATCTCTTCAGCGGGGCGATCCCG
Downstream sequence
AGTCACGCAACCACAGCCCCCCAAGCTCATCTTGTACTCGAAAGGGCTCCAGAGTCCGCGACTGGCACCAGGCCCCCATCTTCCGTGCCCCTCATGCTCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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