Basic Information
VIS ID
TVIS44002339
Fusion event
HTLV-1-SYNE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
152607635/152286500 (Hg38)
End
152607635/152286500 (Hg38)
Orient
-
Location type
Intronic
Target gene
SYNE1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10398/Upstream/1183724; hsa-mir-1202/Downstream/2566860;
Nearest TSS
ENST00000381078/Upstream/4458; ENST00000412161/Downstream/15623;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/477864, chr6-CpG: 26/Downstream/15644
Upstream sequence
tgtctggctcctttcatgattgtgagagtcgttcattttgttgcacggagaaagagttaacccatttttatcattataccatattccactgtCGCCTGgt
Downstream sequence
tgtgaattgttttcactttaagtttttctagtgggtttaatagtggaatctcattgtaattttaatttccatttccccgatgactaatgagattgagtgt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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