Basic Information
VIS ID
TVIS44002344
Fusion event
HTLV-1-ZNF292 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87929039/87219321 (Hg38)
End
87929039/87219321 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF292
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-196a-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p ; hsa-mir-3120-3p ; hsa-mir-32-3p ; hsa-mir-1273g-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-6873-3p ; hsa-mir-4795-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3675-3p ; hsa-mir-7151-5p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-10398/Upstream/8680012; hsa-mir-1202/Downstream/3093421;
Nearest TSS
ENST00000381078/Upstream/5583; ENST00000466062/Downstream/14203;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/63262, chr6-CpG: 30/Downstream/103118
Nearest cancer related gene
ZNF292(TSG, No orient, 0)
Upstream sequence
GGCTAAATTACTTATATGTATAACACTTAATGTTTTTTAGAGTTTAAAATTTATATAGACCCTGAAGAAAAGTACAGTTGTATTCTAGATACTTTTCTTG
Downstream sequence
AGATTATTTAGGAAAATGTGCCCAAATATCACCCTAACCTTTCCCAAGGTATTTAACTAAAGAAGtaaatttttttaaaaaattgtaatatatCTAATGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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