Basic Information
VIS ID
TVIS44002359
Fusion event
HTLV-1-EIF3H integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
117699501/116687262 (Hg38)
End
117699501/116687262 (Hg38)
Orient
-
Location type
Intronic
Target gene
EIF3H
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-511-5p ; hsa-mir-6830-3p ; hsa-mir-4423-3p ; hsa-mir-3613-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-5571-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6888-3p ; hsa-mir-196a-3p ; hsa-mir-661 ; hsa-mir-873-3p ; hsa-mir-4522 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-3120-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-3065-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3664-5p ; hsa-mir-548ah-5p ; hsa-mir-3609
Nearest miRNA
hsa-mir-12123/Upstream/4043679; hsa-mir-10400/Downstream/187466;
Nearest TSS
ENST00000518652/Upstream/29487; ENST00000519443/Downstream/68522;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1017866, chr8-CpG: 21/Downstream/68429
Upstream sequence
cctggaGTTAGGAAATGTGAATAGGCAGTTAGCATGAAAACTGGAATATAAGCAAGAACTGTATGTGTTACCTTTAAAAGGGGCTCATGGAAAAGTGCAT
Downstream sequence
CAACAAGAAAACATCAAAATTCCAGGAAGAATTTTAGGCCAGATACAGTACTAAAGGAATATTGCAAAACAAATTCAATTATTAAGAATCAACAAAGTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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