Basic Information
VIS ID
TVIS44002370
Fusion event
HTLV-1-USP48 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
22059005/21732512 (Hg38)
End
22059005/21732512 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
USP48
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-148b-3p ; hsa-mir-580-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4539 ; hsa-mir-545-5p ; hsa-mir-8063 ; hsa-mir-374b-3p ; hsa-let-7i-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-1468-3p ; hsa-mir-5590-3p ; hsa-mir-545-3p ; hsa-mir-142-5p ; hsa-mir-646 ; hsa-mir-548p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-1305 ; hsa-mir-943 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-1290 ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-1246 ; hsa-mir-892a ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-106a-5p ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-12136/Upstream/744080; hsa-mir-101-1/Downstream/533727;
Nearest TSS
ENST00000473358/Upstream/5942; ENST00000484271/Downstream/314;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/62596, chr1-CpG: 111/Downstream/50124
Upstream sequence
tcagttgactcccacgtcacaaaagaaagatataacctctcagccaGTGACagaaaaaggtctcatctatcacattgagatatatttacaaaaaaagtac
Downstream sequence
atttacagtaaaattttactgtttaataaaatttataacatactttcatgagttttatcaattatgtagtaatattcataattttaaaaacagcactcta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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